NOTCH1 SIGNALING PATHWAY PROMOTES INVASION, SELF-RENEWAL AND GROWTH OF GLIOMA INITIATING CELLS VIA MODULATING CHEMOKINE SYSTEM CXCL12/CXCR4

Notch1 signaling pathway promotes invasion, self-renewal and growth of glioma initiating cells via modulating chemokine system CXCL12/CXCR4

Abstract Background Glioma initiating cells (GICs), also known as glioma stem cells (GSCs), play an important role in the progression and recurrence of glioblastoma multiforme (GBM) due to their potential for self-renewal, multiple differentiation and tumor initiation.In the recent years, Notch1 has been found to be overexpressed in GICs.However, t

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Analisis dan Simulasi Distribusi Suhu Udara pada Kandang Sapi Perah Menggunakan Computational Fluid Dynamics (CFD)

This experiment was conducted to analyze the temperature and relative humidity distribution in dairy barn of Leather Trousers Friesian Holstein (FH) using computational fluid dynamics (CFD) as a basic consideration for dairy barn design.The capacity of the dairy barn was 20 heads of FH with tail to tail model.The dimensions of the dairy barn were:

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Screening gender minority people for harmful alcohol use.

This study identifies how to screen for harmful alcohol use among gender minority (e.g., transgender and gender-expansive) people using brief screening methods and identifies which screening methods perform best among gender-expansive, transfeminine, and transmasculine subgroups, as screening recommendations are not currently available.Using 2018 A

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